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Under e-health reform, public health agencies may need to upgrade their systems in order to be equal partners in health information exchange initiatives with the private health care sector. The Public Health Informatics Profile Toolkit is meant to serve as a guide that you can use to create a comprehensive summary of your agency´s current and projected information system needs and opportunities. The Toolkit provides practical tips and direction for tailoring a profile that realistically reflects your system needs, and can be used to inform your agency decisions and priorities regarding system modernization.